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KMID : 0352519950320030285
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Korea Univercity Medical Journal
1995 Volume.32 No. 3 p.285 ~ p.295
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An Interaction of Etretinate and Polyacetylene Fraction of Ginseng on Lectin Bindings in Palatogenesis
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Kim Sung-Taeg
Park Sun-Hwa
Chun Yong-Hyuck
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Abstract
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The effects of etretinate(Et) and polyacetylene fraction of ginseng (PA) on cell surface glycoconjugates during the palatogenesis were compared in DDY mouse embryos by using lectin histochemistry to understand the background that PA accelerates the palatomorphogenesis and reduces the induction rate and degree of malformations due to Et teratogenicity.
PAS reactivity and lectin binding expressions in control embryos were gradually increased with the growth of palatal shelf proceeded and showed the highest binding affinity for RCA and WGA to the epithelia of shelf prior to elevation, while the affinity for Con A was the highest to the shelf just prior to fusion after elevation.
Shelf epithelia in Et-exposed embryos revealed a significant decrease in bindings of RCA and Con A as well as PAS reactivity; whereas with maternal supplement of PA, the binding expressions of all three lectins were increased in advance with somewhat stronger comparing with those of control, and also PA protected the expressions of glycoconjugates as a control level from the adverse effect of Et on it.
The results suggest that the opposite results happen to be due to Et and PA in palatomorphogenesis might be associated both with the alterations of glycoconjugate metabolism but protective mechanism of PA from Et adversity remains obscure.
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KEYWORD
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